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pentobarbital increases toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. CYP3A4 inducers could increase the metabolism of ifosfamide to its Lively alkylating metabolites.pentobarbital will decrease the extent or effect of clozapine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use W